@article{10.37349/eaa.2026.1009111,
abstract = {This review describes the eosinophil journey through the various physiological and pathophysiological phases, from production, maturation, and activation by chemokines and cytokines [especially eotaxin, interleukin (IL)-5, IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF)], to interaction with the innate and adaptive immune system and tissue homing. Excessive production and activation of eosinophils lead to the release of granule proteins, such as major basic protein, eosinophil cationic protein, eosinophil peroxidase, and others, resulting in inflammation, cell cytotoxicity, and oxidative stress. The pathogenesis, clinical features, diagnostic processes, and the latest therapeutic approaches to the resulting diseases—which affect the upper and lower airways, gastrointestinal tract, skin, myocardium, and may occur systemically—are discussed.},
author = {Di Gioacchino, Mario and Bagnasco, Diego and Braido, Fulvio and Buta, Federica and Caponnetto, Pasquale and Carbone, Roberto Giovanni and Cazzola, Mario and Veen, Willem van de and Vitis, Camilla De and Deng, Linhong and Filho, Nelson Rosario and Gomes, Eva Rebelo and Guida, Giuseppe and Kanjanawasee, Dichapong and Limjunyawong, Nathachit and Maniscalco, Mauro and Morais-Almeida, Mário and Murdaca, Giuseppe and Oh, Jayoung and Paoletti, Giovanni and Patella, Vincenzo and Pereira, Ana Margarida and Prezzavento, Graziella Chiara and Puppo, Francesco and Rhee, Chae-Seo and Ridolo, Erminia and Rijavec, Matija and Rovina, Nikoletta and Roth-Walter, Franziska and Tantilipikorn, Pongsakorn and Yorgancıoğlu, Arzu and Walsh, Garry Michael and Zuberbier, Torsten and Canonica, Giorgio Walter},
doi = {10.37349/eaa.2026.1009111},
journal = {Exploration of Asthma & Allergy},
elocation-id = {1009111},
title = {UpToDate on eosinophils},
url = {https://www.explorationpub.com/Journals/eaa/Article/1009111},
volume = {4},
year = {2026}
}