@article{10.37349/eds.2025.100895,
abstract = {Aim: This study evaluates the efficacy of amino-functionalized mesoporous silica nanoparticles (MSNs) in the controlled release of dexamethasone phosphate (DexaP), aiming to enhance therapeutic outcomes and minimize systemic toxicity. Methods: In this study, amino-functionalized MSNs were synthesized using a modified Stöber process and characterized their chemical and physical properties through various analytical techniques. The study focused on the adsorption and release kinetics of DexaP, employing multiple kinetic models to explore the interaction dynamics. Results: The amino-functionalized MSNs demonstrated effective DexaP loading and controlled release profiles. The kinetic analysis revealed a predominance of chemisorptive interactions, supporting sustained drug release. Enhanced biocompatibility was confirmed through cytotoxicity assays. Conclusions: Amino-functionalized MSNs offer a promising platform for the targeted and controlled delivery of anti-inflammatory drugs, with significant potential to improve patient adherence and reduce adverse effects. The findings advocate for further development of MSNs as a versatile tool in advanced drug delivery systems.},
author = {Galdopórpora, Juan Manuel and Olivera, María Victoria and Ibar, Angelina and Farriol, Darío Hernán and Desimone, Martín Federico and Queirolo, Cynthia Melisa Melián and Pardo, Helena and Tuttolomondo, María Victoria},
doi = {10.37349/eds.2025.100895},
journal = {Exploration of Drug Science},
elocation-id = {100895},
title = {Controlled release of dexamethasone phosphate from modified mesoporous biocompatible silica nanoparticles: synthesis, characterization, and kinetic studies},
url = {https://www.explorationpub.com/Journals/eds/Article/100895},
volume = {3},
year = {2025}
}