TY  - JOUR
T1  - Stapled peptides: targeting protein-protein interactions in drug development
AU  - Zhang, Qian
AU  - Wang, Ziyang
AU  - Mei, Xiaohan
AU  - Chen, Quan
AU  - Zhang, Chunqiu
Y1  - 2024///
JO  - Exploration of Drug Science
VL  - 2
IS  - 2
SP  - 154
EP  - 189
DO  - 10.37349/eds.2024.00041
UR  - https://www.explorationpub.com/Journals/eds/Article/100841
AB  - Protein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promising therapeutic candidate for interfering with PPIs, have a higher degree of α-helicity, improved binding affinity, more resistance to proteolytic digestion, longer serum half-life, and enhanced cell permeability, which exhibits higher pharmacological activity compared with small molecule drugs and biologics. This review outlined the continuous progress of stapled peptides mainly concerning the design principle, structural stability, bioactivity, cell permeability, and potential applications in therapeutics, which is aimed at providing a broad reference for the design and exploration of stapled peptides with enhanced biological and pharmacokinetic properties as the next-generation therapeutic peptide drugs targeting various diseases.
ER  -