@article{10.37349/eds.2023.00003,
abstract = {Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor
treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous
polydopamine (MPDA) nanocomposites for killing tumor cells.
Methods: MPDA nanoparticles were synthesized and functionalized with camptothecin (CPT) payload and
manganese dioxide (MnO2) coating to construct MPDA-CPT-MnO2 nanocomposites.
Results: When uptaken by tumor cells, the nanocomposites can degrade to produce O2, release CPT, and
generate manganese (Mn2+) under the stimulation of hydrogen peroxide (H2O2) and acid. The released CPT
and Mn2+ can act as chemotherapeutic drug and Fenton-like agent, respectively. Abundant reactive oxygen
species (ROS) are generated in 4T1 tumor cells through an Mn2+-mediated Fenton-like reaction. After that, the
generated Mn4+ can react with glutathione (GSH) through redox reaction to produce Mn2+ and deplete GSH,
disrupting the reducing capacity and benefiting the production of ROS in tumor cells. Under laser irradiation,
the nanocomposites can generate hyperthermia to promote the production of ROS.
Conclusions: The developed MPDA-CPT-MnO2 nanocomposites can kill tumor cells through collaborative
chemo/photothermal/chemodynamic therapy (CDT).},
author = {Ouyang, Yi and Chen, Yan and Xu, Ting and Sun, Yihao and Zhao, Sheng and Chen, Chunmei and Tan, Yixin and He, Liang and Liu, Hui},
doi = {10.37349/eds.2023.00003},
journal = {Exploration of Drug Science},
pages = {18--30},
title = {{Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment}},
url = {https://www.explorationpub.com/Journals/eds/Article/10083},
volume = {1},
year = {2023},
number = {1},
}