@article{10.37349/eds.2026.1008163,
abstract = {Aim: This study investigated the anti-inflammatory effect of the extract and fractions of Eucalyptus camaldulensis and also profiled the secondary metabolites of its most active fraction. Methods: The leaves of E. camaldulensis were collected, authenticated and extracted with methanol. The extract (100, 200, and 400 mg/kg), normal saline (negative control), and aspirin (positive control) were administered orally to egg-induced paw oedema rats of five groups of five rats each. The extract was partitioned, and each of the solvent fractions was assayed for its anti-inflammatory activity. The results obtained were subjected to one-way analysis of variance (ANOVA) followed by Bonferroni post hoc tests, and p < 0.05 was considered significant. Also, the most active fraction was subjected to gas chromatography-mass spectrometry (GC-MS) analysis. Results: The extract at 100 mg/kg demonstrated the best anti-inflammatory effect at 29%, while the n-hexane (N-HEX) fraction gave the highest inflammatory inhibition at 43%. α-Phellandrene, o-cymene, n-hexadecanoic acid, and beta-sitosterol were identified as the most abundant compounds in the N-HEX fraction. Conclusions: The study concluded that the methanol extract of E. camaldulensis possesses good anti-inflammatory properties, and its non-polar fraction was responsible for the observed activity. Bioassay-guided purification of anti-inflammatory constituents of the N-HEX fraction is recommended for future studies.},
author = {Faloye, Kolade O. and Ekundayo, Oluwapelumi E. and Oke, Silas A. and Nwogu, Augusta U. and Adesida, Stephen A. and Olanudun, Esther A. and Makinde, Boluwaji O. and Anyim, Godwin and Bakare, Maryam O. and Famuyiwa, Samson O.},
doi = {10.37349/eds.2026.1008163},
journal = {Exploration of Drug Science},
elocation-id = {1008163},
title = {Anti-inflammatory activity and secondary metabolite profiling of Eucalyptus camaldulensis (Myrtaceae)},
url = {https://www.explorationpub.com/Journals/eds/Article/1008163},
volume = {4},
year = {2026}
}