TY  - JOUR
TI  - Granulomatosis with polyangiitis: functional activity of neutrophils and spontaneous NETosis (clinical case)
AU  - Reshetnyak, Tatiana M.
AU  - Vorkel, Evgeniya N.
AU  - Nurbaeva, Kamila S.
AU  - Adamanskaya, Ekaterina-Iva A.
AU  - Galkina, Sofia V.
AU  - Sveshnikova, Anastasia N.
AU  - Lila, Aleksander M.
PY  - 2026
JO  - Exploration of Musculoskeletal Diseases
VL  - 4
SP  - 1007136
DO  - 10.37349/emd.2026.1007136
UR  - https://www.explorationpub.com/Journals/emd/Article/1007136
AB  - The clinical significance of neutrophil activation and NETosis in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is the focus of ongoing research. In the presented clinical case of active granulomatosis with polyangiitis (GPA) with multi-organ damage associated with ANCA-proteinase 3 (PR3), a high proportion of neutrophils transitioning to NETosis (97.9%) was detected. This case report aimed to characterize spontaneous NETosis and neutrophil functional activity in a patient with severe active PR3-positive GPA in order to determine whether a distinct pattern of neutrophil activation could be identified. In this case, NETosis was completely represented by the suicidal variant, with no evidence of vital NETosis or extracellular DNA structures formed by other leukocytes. This observation adds to the current understanding of the key role of neutrophils and NETs in the pathogenesis of AAV. Unlike previous studies that mainly quantified circulating NET markers or stimulated NET formation in vitro, this report provides an integrated assessment of spontaneous NETosis phenotype together with neutrophil chemotaxis and thromboinflammatory behavior in an individual patient with active GPA.
ER  -