TY  - JOUR
T1  - Therapeutic potential of extracellular vesicles in Parkinson' s disease
AU  - Teixeira, Michelli Ramires
AU  - Alievi, Anderson Lucas
AU  - da Costa, Vitor Rodrigues
AU  - Dias Pinto, João Rafael
AU  - Araldi, Rodrigo Pinheiro
Y1  - 2023///
JO  - Exploration of Neuroscience
VL  - 2
IS  - 3
SP  - 106
EP  - 122
DO  - 10.37349/en.2023.00016
UR  - www.explorationpub.com/Journals/en/Article/100616
AB  - Globally, the incidence of Parkinson’s disease (PD) is increasing faster than other neurodegenerative disorders. Neuropathologically, PD is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta due to the accumulation of aggregates of misfolded α-synuclein (α-Syn) in the cytoplasm of these neurons, forming Lewy bodies. Extracellular vesicles (EVs) are associated with the spread of α-Syn to different brain areas. However, at the same time that these EVs contribute to the pathophysiology of PD, they can also be explored as therapeutic, serving as a vehicle to deliver specific molecules, since these vesicles can easily cross the blood-brain barrier. Thus, this review summarizes the recent progress in EVs as a therapeutic strategy for PD, focusing on their delivery to the brain, and discusses the potential challenges and future directions in this field.
ER  -