@article{10.37349/en.2026.1006146,
abstract = {Aim: Neuropathic pain (NP) is common in cancer patients, but its relationship with haematological inflammatory markers remains poorly understood. This study explored the association between NP and haematological parameters in Nigerian cancer patients. Methods: This cross-sectional study enrolled 90 patients with solid tumours from the University of Ilorin Teaching Hospital. Pain severity was assessed using the Numerical Rating Scale, while NP was evaluated with the painDETECT questionnaire. Complete blood count parameters were analysed, and derived inflammatory indices were calculated. Statistical analyses employed chi-square tests, Spearman’s correlation, and binary logistic regression. Results: NP was present in 21.1% of patients. Significant associations with NP were observed for haemoglobin (p = 0.006), absolute lymphocyte count (p = 0.003), platelet-to-lymphocyte ratio (PLR, p = 0.015), haemoglobin-to-platelet ratio (HPR, p = 0.001), and systemic immune-inflammation index (SII, p < 0.001). Correlation analysis showed NP positively correlated with platelet count (ρ = 0.23, p = 0.029), absolute neutrophil count (ρ = 0.263, p = 0.012), neutrophil-to-lymphocyte ratio (NLR, ρ = 0.248, p = 0.019), SII (ρ = 0.215, p = 0.045), and neutrophil-platelet score (NPS, ρ = 0.248, p = 0.018), while correlating negatively with haemoglobin (ρ = –0.223, p = 0.034). Logistic regression identified haemoglobin, platelet count, absolute lymphocyte count, absolute neutrophil count, NLR, and HPR as independent predictors of NP. Conclusions: Haematological parameters reflecting systemic inflammation are significantly associated with NP in cancer patients. These readily available indices may serve as useful adjuncts for identifying at-risk patients, particularly in resource-limited settings. Prospective studies are warranted to validate these findings.},
author = {Izuegbuna, Ogochukwu and Oyewale, Saburi and Adindu, Chijioke Chidindu and Oguntola, Saliu and Woods-Ali, Tiwalade and Kolawole, Israel},
doi = {10.37349/en.2026.1006146},
journal = {Exploration of Neuroscience},
elocation-id = {1006146},
title = {Haematological indices as markers of neuropathic pain in Nigerian cancer patients: a cross-sectional study},
url = {https://www.explorationpub.com/Journals/en/Article/1006146},
volume = {5},
year = {2026}
}