@article{10.37349/edd.2025.100571,
abstract = {Pancreatic cystic lesions are frequently found incidentally on cross-sectional imaging and are broadly classified into mucinous and non-mucinous cysts. While some exhibit benign behavior, others have a malignant potential and are considered noninvasive precursors of pancreatic ductal adenocarcinoma. Guidelines from various societies propose risk stratification based on morphologic features and cyst fluid analysis. Fluid analysis through EUS-guided fine needle aspiration contributes to improved classification and recently, targeted DNA or RNA-based next generation sequencing is emerging as a critical investigation tool for diagnostic confirmation and risk stratification of pancreatic cysts. Each of these modalities has specific strengths and limitations, highlighting the need for a multi-modal approach for comprehensive assessment to guide clinical decision making. In this perspective, we aim to provide a thorough clinicopathologic framework for diagnosing and risk stratifying pancreatic cysts encompassing imaging findings, cyst fluid analyses, and next generation sequencing.},
author = {El Asmar, Rudy and Bizri, Nazih and Tirukkovalur, Nikhil Vaishnav and Tcharni, Adam and Dasyam, Navya and AlMasri, Samer},
doi = {10.37349/edd.2025.100571},
journal = {Exploration of Digestive Diseases},
elocation-id = {100571},
title = {Molecular insights into pancreatic cysts: navigating diagnosis and precision management},
url = {https://www.explorationpub.com/Journals/edd/Article/100571},
volume = {4},
year = {2025}
}