TY  - JOUR
T1  - The impact of hepatitis B virus (HBV) splicing on HBV replication and disease progression
AU  - McCoullough, Laura C.
AU  - Littlejohn, Margaret
AU  - Revill, Peter A.
Y1  - 2024///
JO  - Exploration of Digestive Diseases
VL  - 3
IS  - 4
SP  - 326
EP  - 343
DO  - 10.37349/edd.2024.00054
UR  - https://www.explorationpub.com/Journals/edd/Article/100554
AB  - Chronic hepatitis B (CHB) disease caused by persistent infection with hepatitis B virus (HBV) is a global health problem affecting almost 300 million people worldwide, resulting in up to 1 million deaths each year. The factors contributing to HBV mediated liver disease are yet to be fully resolved, however, multiple studies have suggested that HBV splice variants may be a contributing factor. Recent studies have indicated that novel fusion proteins encoded by splice variants, or the splice-derived RNA itself, may impact replication of wild-type HBV, although the direct mechanisms for these interactions are largely unknown. This review explores the latest knowledge regarding the contribution of splice variants to liver disease and their impact on HBV replication.
ER  -