TY  - JOUR
T1  - Extracellular vesicles in metabolic dysfunction associated fatty liver disease : mechanisms, diagnostic and therapeutic implications
AU  - Wu, Zongmei
AU  - Xia, Mengmeng
AU  - Salas, Sandra Serna
AU  - Trillos-Almanza, Maria Camila
AU  - Aguilar, Magnolia Martinez
AU  - Arroyave-Ospina, Johanna C.
AU  - Wang, Junyu
AU  - Arrese, Marco
AU  - Sydor, Svenja
AU  - Bechmann, Lars P.
AU  - van Vilsteren, Frederike GI
AU  - Blokzijl, Hans
AU  - Moshage, Han
Y1  - 2022///
JO  - Exploration of Digestive Diseases
VL  - 1
IS  -  1
SP  - 4
EP  - 20
DO  - 10.37349/edd.2022.00002
UR  - https://www.explorationpub.com/Journals/edd/Article/10052
AB  - The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steatohepatitis (NASH) with advanced fibrosis or cirrhosis are affecting global health. Extracellular vesicles (EVs) are released by all cell types and are important in cell-to-cell communication and maintaining homeostasis, but they also play a role in the pathogenesis of various diseases. EVs contain biological information such as lipids, proteins, messenger RNAs (mRNAs), small RNAs, and DNA, and they act on (distant) target cells. The cargo of EVs is dependent on the type and the state of the releasing cell. EVs have been proposed as biomarkers, prognostic, and even therapeutic agents, also in the context of liver diseases. This review aims to give an overview of the current knowledge on EVs in MAFLD, including the role and interaction of EVs with different cell types in the liver. Several aspects of EVs, including their origin, characteristics, cargo, and functions are reviewed. Moreover, the potential of EVs as targets for the treatment of MAFLD is discussed.
ER  -