TY  - JOUR
TI  - Therapeutic role of JAK inhibitors in hepatogastrointestinal diseases
AU  - Elghannam, Maged Tharwat
AU  - Hassanien, Moataz Hassan
AU  - Ameen, Yosry Abdelrahman
AU  - Turky, Emad Abdelwahab
AU  - Elattar, Gamal Mohammed
AU  - Elray, Ahmed Aly
AU  - Eltalkawy, Mohammed Darwish
PY  - 2026
JO  - Exploration of Digestive Diseases
VL  - 5
SP  - 1005122
DO  - 10.37349/edd.2026.1005122
UR  - https://www.explorationpub.com/Journals/edd/Article/1005122
AB  - Janus kinase (JAK) inhibitors represent a major advancement in the management of immune-mediated inflammatory diseases. A balanced approach that carefully weighs therapeutic benefits against potential risks is essential. Through appropriate patient selection, close monitoring, and open physician–patient communication, the clinical potential of JAK inhibitors can be optimized while minimizing adverse outcomes. Nine JAK inhibitors have demonstrated utility in hepatogastrointestinal disorders; however, only two have FDA approval. JAK inhibitors are classified into reversible (competitive) and irreversible (covalent) inhibitors according to their chemical binding with amino acids. This review discusses the safety profile, adverse effects, and molecular selectivity of JAK inhibitors, and highlights their therapeutic roles in hepatogastrointestinal diseases, including inflammatory bowel disease, hepatic fibrosis, hepatocellular carcinoma, autoimmune diseases associated with cancer therapy in post-transplant patients, eosinophilic esophagitis, metabolic syndrome, and metabolic dysfunction-associated steatotic liver disease, and acute graft-versus-host disease following liver transplantation.
ER  -