TY  - JOUR
TI  - Understanding liver and digestive diseases: a paved road to improve diagnosis, management, and treatment
AU  - Bergheim, Ina
AU  - Cadranel, Jean Francois
AU  - Chen, Jian-Guo
AU  - Ding, Wen-Xing
AU  - Eferl, Robert
AU  - Garcia-Ruiz, Carmen
AU  - Jaeschke, Hartmut
AU  - Kazerouni, Firouzeh
AU  - Lonardo, Amedeo
AU  - Mann, Derek A.
AU  - Méndez-Sánchez, Nahum
AU  - Mokhtari, Camelia
AU  - Moshage, Han
AU  - Raggi, Chiara
AU  - Strnad, Pavel
AU  - Tirosh, Oren
AU  - Zougmore, Honoré Tegwende
AU  - Fernandez-Checa, Jose C
PY  - 2026
JO  - Exploration of Digestive Diseases
VL  - 5
SP  - 1005110
DO  - 10.37349/edd.2026.1005110
UR  - https://www.explorationpub.com/Journals/edd/Article/1005110
AB  - Digestive diseases comprise a diverse range of illnesses, which are prevalent worldwide and represent an important health issue. This is particularly relevant for the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) due to its close association with the obesity pandemic, contributing to the escalation of MASLD as the most common form of chronic liver disease, and the main cause of liver cancer. Not only does MASLD reflect the deterioration of liver health, but it also has far-reaching consequences for the development of extrahepatic digestive diseases. Along with the progression of liver and digestive diseases to liver, colorectal and pancreatic cancer, the onset of inflammation in diseases of the digestive tract, drug-induced liver injury, and cholestasis, drives and contributes to the rise of these diseases in the future, which merit the attention of clinical and translational research to increase our understanding of the pathogenic mechanisms underlying these disorders in order to improve the diagnosis, management, and treatment. With this goal in mind, the current collaborative review gathers experts in a wide range of liver and digestive diseases to provide an up-to-date overview of the mechanisms of disease and identify novel strategies for the improvement of these important health issues.
ER  -