TY  - JOUR
T1  - The effects of post-translational modifications on alpha-synuclein aggregation and immune cell activation in Parkinson’s disease
AU  - Khan, Zaina
AU  - Jung, Yoo Jin
Y1  - 2023///
JO  - Exploration of Neuroprotective Therapy
VL  - 3
IS  - 5
SP  - 281
EP  - 298
DO  - 10.37349/ent.2023.00052
UR  - https://www.explorationpub.com/Journals/ent/Article/100452
AB  - Post-translational modifications (PTMs) of alpha-synuclein (α-syn) can alter protein aggregation propensity to affect α-syn oligomer and fibril formation. The inflammatory response in Parkinson’s disease (PD) is mediated by microglia, astrocytes, T cells, B cells, macrophages, and neutrophils, which respond to α-syn aggregates in an attempt to clear synucleinopathy and restore brain homeostasis. This review focuses on the effects of PTMs on α-syn aggregation and cell-specific immune responses to α-syn aggregates in the context of PD.
ER  -