TY  - JOUR
T1  - Blockage of thrombospondin 4 secreted by spinal astrocytes may be a promising therapeutic target in the treatment of neuropathic pain
AU  - Düzenli, Neslihan
AU  - Can, Cenk
AU  - Önal, Aytül
Y1  - 2022///
JO  - Exploration of Neuroprotective Therapy
VL  - 2
IS  - 5
SP  - 226
EP  - 241
DO  - 10.37349/ent.2022.00030
UR  - https://www.explorationpub.com/Journals/ent/Article/100430
AB  - Neuropathic pain (NP), which is difficult to treat, remains a heavy burden for both individuals and society. The efficacy of current treatments is insufficient. The pathophysiology of NP is still not fully elucidated, and there is a need to explore new therapeutic targets to develop more effective treatment strategies. Recent studies showed that thrombospondin 4 (TSP4) protein expression is increased in the spinal cord following nervous system injury and that blocking or inhibiting this increase improves NP. In this review, it has been aimed to present the evidence for the role of TSP4 in the mechanisms of NP development and to evaluate the therapeutic potential of TSP4 blockade in the treatment of NP.
ER  -