TY  - JOUR
T1  - Peroxisomes in intracellular cholesterol transport: from basic physiology to brain pathology
A1  - Xiao, Jian
A1  - Song, Bao-liang
A1  - Luo, Jie
Y1  - 2021///
KW  - peroxisome
KW  - cholesterol transport
KW  - nervous system
KW  - peroxisomal disorders
JF  - Exploration of Neuroprotective Therapy
VL  - 1
IS  - 3
SP  - 127
EP  - 145
DO  - 10.37349/ent.2021.00011
UR  - https://www.explorationpub.com/Journals/ent/Article/100411
N2  - Peroxisomes are actively involved in the metabolism of various lipids including fatty acids, ether phospholipids, bile acids as well as the processing of reactive oxygen and nitrogen species. Recent studies show that peroxisomes can regulate cholesterol homeostasis by mediating cholesterol transport from the lysosomes to the endoplasmic reticulum and towards primary cilium as well. Disruptions of peroxisome biogenesis or functions lead to peroxisomal disorders that usually involve neurological deficits. Peroxisomal dysfunction is also linked to several neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In many peroxisomal disorders and neurodegenerative diseases, aberrant cholesterol accumulation is frequently encountered yet largely neglected. This review discusses the current understanding of the mechanisms by which peroxisomes facilitate cholesterol trafficking within the cell and the pathological conditions related to impaired cholesterol transport by peroxisomes, with the hope to inspire future development of the treatments for peroxisomal disorders and neurodegenerative diseases.
ER  -