@article{10.37349/ent.2025.1004109,
abstract = {Aim: Our previous research (Abstract, J Vessels Circ. 2021;2:0–0) suggested an increased risk of thrombotic events, including ischemic strokes, in patients with COVID-19. This study aims to determine the mortality rate and its predictors in patients with stroke and concurrent COVID-19 infection. Methods: A retrospective analysis was conducted on stroke patients admitted to three Iranian referral hospitals within a 3-month period during the COVID-19 pandemic (COV-pos and COV-neg groups). The mortality rate was compared to a similar period one year before the pandemic (non-COV group). The Cox proportional hazards model was used to assess the independent and interactive effects of various variables on mortality. Results: Among 124 stroke admissions, 59 (47.6%) had confirmed COVID-19 infection. The COV-pos group had a significantly higher initial NIHSS score (P = 0.001) compared to other groups. Mortality rates were 49.2%, 24.2%, and 17.3% in the COV-pos, COV-neg, and non-COV groups, respectively (P < 0.001). Posterior cerebral artery (PCA) stroke (HR = 65.099), internal carotid artery (ICA) stroke (HR = 19.102), and a history of diabetes mellitus (HR = 3.824) were identified as the most significant predictors of mortality in patients with stroke and COVID-19 infection. Conclusions: Stroke patients with COVID-19 infection exhibited a significantly higher mortality rate compared to patients without COVID-19. The type of stroke involving the PCA or ICA and a history of diabetes emerged as the strongest predictors of mortality in the studied population.},
author = {Almasi-Dooghaee, Mostafa and Tabatabaee, Seyedehnarges and Moghadas, Fatemeh and Khoeini, Tara and Ghamsari, Mona Ramezani and Lotfi, Tayebeh and Heidari, Matineh and Shafiei, Zakieh and Yazdani, Roya and Mirzaasgari, Zahra and Tabatabaei, Seyed Mohammad and Moghaddasi, Mehdi and Vahabie, Abdol-Hossein},
doi = {10.37349/ent.2025.1004109},
journal = {Exploration of Neuroprotective Therapy},
elocation-id = {1004109},
title = {Higher mortality in stroke patients with active COVID-19 infection},
url = {https://www.explorationpub.com/Journals/ent/Article/1004109},
volume = {5},
year = {2025}
}