@article{10.37349/ei.2022.00073,
abstract = {Chemokines are homeostatic or inflammatory small proteins regulating immune cell migration and are structurally characterized by cysteine disulfide bridges. Around 50 human chemokines binding almost 20 seven-transmembrane G-protein coupled receptors have been discovered. The finding that two of them were the main human immunodeficiency virus (HIV) co-receptors intensified the research on the binding mechanism to block the viral entrance. Blockade of chemokine/chemokine receptor signaling ultimately modulates cell migration, then immune responses. Particular nanotechnologies can be designed to interfere with chemokine signaling or to exploit the ligand-receptor interaction. Surface chemical modification of nanomaterials with chemokines or specific peptides can find several applications in bio-medicine, from tissue-specific drug delivery to reduced cell migration in pathological conditions. Recent highlights on peculiar chemokine-nanoparticle design and their potential to modulate immune responses will be discussed.},
author = {Bardi, Giuseppe},
doi = {10.37349/ei.2022.00073},
journal = {Exploration of Immunology},
pages = {637--647},
title = {{Chemokines and nanomaterials: interaction for useful immune-applications}},
url = {https://www.explorationpub.com/Journals/ei/Article/100373},
volume = {2},
year = {2022},
number = {4}
}