TY  - JOUR
T1  - Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
A1  - Furue, Masutaka
A1  - Furue, Mihoko
Y1  - 2021///
KW  - IL-22
KW  - IL-22 receptor
KW  - aryl hydrocarbon receptor
KW  - skin barrier
KW  - keratinocyte
KW  - atopic dermatitis
KW  - psoriasis
JF  - Explor Immunol
SP  - 37
EP  - 47
DO  - 10.37349/ei.2021.00005
UR  - https://www.explorationpub.com/Journals/ei/Article/10035
N2  - Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1(IL-22R1) and the IL-10 receptor 2 (IL-10R2). As the IL-22R1/IL-10R2 heterodimer is preferentially expressed on border tissue between the host and the environment, IL-22 is believed to be involved in border defense. Epidermal keratinocytes are the firstline skin barrier and express IL-22R1/IL-10R2. IL-22 increases keratinocyte proliferation but inhibits differentiation. Aryl hydrocarbon receptor (AHR) is a chemical sensor and an essential transcription factor for IL-22 production. In addition, AHR also upregulates the production of barrier-related proteins such as filaggrin in keratinocytes, suggesting a pivotal role for the AHR-IL-22 axis in regulating the physiological skin barrier. Although IL-22 signatures are elevated in atopic dermatitis and psoriasis, their pathogenic and/or protective implications are not fully understood.
ER  -