@article{10.37349/ei.2022.00044,
abstract = {Aim: The aim of this article is to characterize in detail the $\gamma$$\delta$ T lymphocytes from an adult patient with primary cutaneous T-cell lymphoma of $\gamma$$\delta$ subtype ($\gamma$$\delta$ CTCL). Methods: Here this article reports trajectory mapping on high-resolution differentiation trajectories of $\gamma$$\delta$ T lymphocytes digitally extracted from a scRNAseq dataset. Results: In the patch-to-plaque progression of CTCL, the TCRV$\gamma$non9 subset of $\gamma$$\delta$ T cells differentiated from naive T cells (Tn) and central memory T cells (Tcm) to abundant effector memory T cells (Tem) while other cutaneous $\gamma$$\delta$ T and CD8 T cells remained unchanged. Conclusions: This transcriptomic switch underlies the emergence of a CTCL-like progression of the TCRV$\gamma$non9 $\gamma$$\delta$ T subtype and suggests new routes for treating these diseases.},
author = {Cerapio, Juan-Pablo and Perrier, Marion and Pont, Fréderic and Laurent, Camille and Bertani, Stéphane and Fournie, Jean‐Jacques},
doi = {10.37349/ei.2022.00044},
journal = {Exploration of Immunology},
pages = {185--198},
title = {{Single ‐ cell differentiation trajectories define early stages of a human cutaneous T-cell lymphoma}},
url = {https://www.explorationpub.com/Journals/ei/Article/100344},
volume = {2},
year = {2022}
number = {2}
}