@article{10.37349/ei.2022.00036,
abstract = {$\gamma$$\delta$ T cells are one of the immune cell types that express antigen receptors. $\gamma$$\delta$ T cells are able to recognize pathogens or cancer cells independently of human leukocyte antigen restriction, which is an important feature of $\alpha$$\beta$ T cells. Therefore, $\gamma$$\delta$ T cells are considered the bridge between innate and adaptive immunity. These cells exhibit important roles in immune surveillance, exert immune defense against tumors and have become promising effector cells for cancer immunotherapy. However, in particular circumstances, the tumor microenvironment seems to render $\gamma$$\delta$ T cells immunosuppressive and even tumor-promoting, emphasizing the importance of regulating $\gamma$$\delta$ T functions in realizing their translation into practical cancer immunotherapy. In recent years, increasing evidence has demonstrated that the intratumoral and peritumoral microbiota can have complex effects on tumor immunology. Thus, understanding the role of microbiota in the crosstalk between $\gamma$$\delta$ T cells and tumors will provide insights for developing adjuvant immunotherapy with precise regulation of tumor-related microbiota. We will discuss the effects of microbiota on $\gamma$$\delta$ T cells that might shape the T cell receptor repertoire and dissect the roles of microbiota in some common tumors, with implications for future cancer therapy.},
author = {Wang, Huidi and Li, Jie and He, Yan and Yin, Jia},
doi = {10.37349/ei.2022.00036},
journal = {Exploration of Immunology},
pages = {48--63},
title = {{The microbiota is a potential mediator of the crosstalk between $\gamma$$\delta$ T cells and tumors}},
url = {https://www.explorationpub.com/Journals/ei/Article/100336},
volume = {2},
year = {2022},
number = {1}
}