TY - JOUR TI - Autophagy, apoptosis, and human leukocyte antigen class II-mediated immune recognition in diffuse large B-cell lymphoma models AU - Pepe, Ludovica AU - Fiorentino, Vincenzo PY - 2026 JO - Exploration of Immunology VL - 6 SP - 1003272 DO - 10.37349/ei.2026.1003272 UR - https://www.explorationpub.com/Journals/ei/Article/1003272 AB - This Letter examines evidence that ganoderic acid DM (GA-DM) is associated with caspase activation, changes in autophagy markers, and increased human leukocyte antigen (HLA) class II-restricted interleukin-2 (IL-2) release in a peptide-specific T-cell hybridoma assay using engineered diffuse large B-cell lymphoma (DLBCL) models, and outlines the viability-controlled tissue and ex vivo studies needed to assess autophagic flux and clinical relevance. ER -