TY  - JOUR
T1  - COVID-19 vaccine and immune response
A1  - Hintistan, Sevilay
A1  - Demirag, Hatice
Y1  - 2021///
KW  - COVID-19
KW  - vaccine
KW  - immune response
JF  - Exploration of Immunology
VL  - 1
IS  - 5
SP  - 341
EP  - 355
DO  - 10.37349/ei.2021.00023
UR  - https://www.explorationpub.com/Journals/ei/Article/100323
N2  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; βCoV), the causative agent of coronavirus disease 2019 (COVID-19), causes severe lower respiratory tract infections and acute respiratory failure syndrome (ARDS). Deaths due to the ongoing COVID-19 pandemic for more than a year are still seen worldwide. Therefore, vaccine trials have gained importance. The discovery of the genome and protein structure of SARS-CoV-2 in a short time allowed the development of nucleic acid-based vaccines (mRNA and DNA vaccines), vector vaccines, inactivated virus vaccines, protein-based vaccines, virus-like particle vaccines, and live attenuated virus vaccines. Many companies, universities, and institutes around the world continue to develop effective vaccines against SARS-CoV-2. In this review, the structural features, classification, genome, and intracellular entry of SARS-CoV-2 coronaviruses, stimulation of the immune system and immunity, COVID-19 vaccine types, and the latest status of clinical trials of these vaccines have been reviewed.
ER  -