TY  - JOUR
TI  - Skin aging and immunosenescence
AU  - Strbo, Natasa
AU  - Younis, Sujad
AU  - Frasca, Daniela
AU  - Paganelli, Alessia
PY  - 2025
JO  - Exploration of Immunology
VL  - 5
SP  - 1003218
DO  - 10.37349/ei.2025.1003218
UR  - https://www.explorationpub.com/Journals/ei/Article/1003218
AB  - The skin covers the entire surface of the body and therefore is the largest organ in humans. The skin has various functions, primarily defence from infections and trauma. With aging, profound changes occur that compromise its key functions, leading to impaired barrier protection and immune responses. This is in part due to the increased low-grade systemic inflammation known as inflammaging, driven by senescent cells, and release of pro-inflammatory cytokines, to which the skin also significantly contributes. As a consequence of inflammaging, the skin’s function is compromized. The cellular and molecular components involved are summarized in this review.
ER  -