TY  - JOUR
T1  - Yeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family
AU  - Manon, Stéphen
Y1  - 2022///
JO  - Exploration of Targeted Anti-tumor Therapy
VL  - 3
IS  -  2
SP  - 128
EP  - 148
DO  - 10.37349/etat.2022.00076
UR  - https://www.explorationpub.com/Journals/etat/Article/100276
AB  - The budding yeast Saccharomyces cerevisiae, a favorite model in biology, does not contain any protein of the Bcl-2 family. From initial experiments with two-hybrid systems to the heterologous expression of human Bcl-2 family members, and the characterization of several forms of yeast programmed cell death, it has however always been a powerful tool to gain information on the mechanisms of apoptosis in general and on Bcl-2 family in particular. This is a short survey of 25 years of experiments that have provided, and at times initiated, insights into the molecular mechanisms underlying the function of Bcl-2 family members.
ER  -