@article{10.37349/etat.2022.00072,
abstract = {The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of particular note are two-pore channels (TPCs), a group of recently identified Ca2+-channels, located within the endolysosomal system. TPC2 has recently emerged as an intracellular ion channel of significant pathophysiological relevance, specifically in cancer, and interest in its role as an anti-cancer drug target has begun to be explored. Herein, an overview of the cancer-related functions of TPC2 and a discussion of its potential as a target for therapeutic intervention, including a summary of clinical trials examining the TPC2 inhibitors, naringenin, tetrandrine, and verapamil for the treatment of various cancers is provided.}，
author = {Skelding, Kathryn A and Barry, Daniel L and Theron, Danielle Z and Lincz, Lisa F},
doi = {10.37349/etat.2022.00072},
journal = {Exploration of Targeted Anti-tumor Therapy},
pages = {62--89},
title = {{Targeting the two-pore channel 2 in cancer progression and metastasis}},
url = {https://www.explorationpub.com/Journals/etat/Article/100272},
volume = {3},
year = {2022},
number = {1}
}