abstract = {All-trans retinoic acid (ATRA) induces complete remission in a high proportion of acute promyelocytic leukemia (APL). Nevertheless it is be associated with adverse drug reactions that might be life-threatening including differentiation syndrome, myocarditis, myositis, Sweet's syndrome and ulcers. We describe a case of APL who during induction therapy developed ATRA syndrome, cardiac arrhythmia and multiple episodes of intestinal necrosis that required surgery. In particular, we report here for the first intestinal necrosis attributable to ATRA treatment in the absence of histological evidence of promyelocytes infiltration or leukocytoclastic vasculitis.},
author = {Ferla, Valeria and Sciumé, Mariarita and Gianelli, Umberto and Baldini, Luca and Fracchiolla, Nicola Stefano},
doi = {10.37349/etat.2020.00007},
issn = {2692-3114},
journal = {Exploration of Targeted Anti-tumor Therapy},
keywords = {acute promyelocytic leukemia,adverse drug reaction,all-trans retinoic acid},
number = {2},
pages = {109-116},
title = {{Multiple adverse drug reactions during all-trans retinoic acid treatment for acute promyelocytic leukemia: differentiation syndrome, bradycardia, intestinal necrosis}},
url = {https://www.explorationpub.com/Journals/etat/Article/10027},
volume = {1},
year = {2020}
}