TY  - JOUR
T1  - Interface between obesity with dysfunctional metabolism and inflammation, and the triple-negative breast cancer in African American women
A1  - Rygiel, Katarzyna
Y1  - 2021///
KW  - triple-negative breast cancer
KW  - African American
KW  - body mass index
KW  - waist-to-hip ratio
KW  - central obesity
KW  - cytokines
KW  - inflammation
KW  - tumor microenvironment
JF  - Exploration of Targeted Anti-tumor
VL  - 2
SP  - 602
EP  - 616
DO  - 10.37349/etat.2021.00066
UR  - https://www.explorationpub.com/Journals/etat/Article/100266
N2  - Obesity has dramatically increased over the past fifty years. In the last decade, it has been noted that augmented body mass, metabolic abnormalities, and the relevant “obese” tumor microenvironment (TME) are connected with signaling molecular networks, which in turn, may contribute to aggressive tumor biology in some patients with breast malignancies. This article presents the associations between obesity, metabolic derangements, inflammatory processes in the adipose tissue or TME, and aggressive behavior of triple-negative breast cancer (TNBC) in African American (AA) women. It also describes some abnormal molecular signaling patterns in the “obese” TME with relevance to TNBC biology. Ethnic disparities in TNBC can be due to a variety of biological features (e.g., genetic mutations and tumor heterogeneity), comorbidities (e.g., cardio-metabolic diseases, including diabetes mellitus), and reproductive factors (e.g., multiparty or short breastfeeding period). Such a constellation of biological variables potentially leads to the association between obesity, metabolic derangements, inflammatory processes in the adipose tissue or TME, and aggressive behavior of TNBC in AA women. Since the TNBC and its TME can display very aggressive behavior, it is crucial that the afflicted AA women make efforts to maintain healthy body weight, “flexible” metabolism, and a well-functioning immune system. Further studies are merited to explore the multi-disciplinary factors that can affect TNBC prevention, management, and outcomes to optimize treatment strategies and survival among AA women.
ER  -