abstract = {Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters (MCT, MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump, and the sodium-hydrogen exchanger 1. This review will describe progress in the development of inhibitors to these targets.},
author = {Ward, Carol and Meehan, James and Gray, Mark E and Murray, Alan F and Argyle, David J and Kunkler, Ian H and Langdon, Simon P},
doi = {10.37349/etat.2020.00005},
issn = {2692-3114},
journal = {Exploration of Targeted Anti-tumor Therapy},
keywords = {acidosis,carbonic anhydrase IX,hypoxia,inhibitor,monocarboxylate transporter 1,monocarboxylate transporter 4,sodium-hydrogen exchanger 1,tumour pH,vacuolar-type H+-ATPase proton pump},
pages = {71-100},
title = {{The impact of tumour pH on cancer progression: strategies for clinical intervention}},
url = {https://www.explorationpub.com/Journals/etat/Article/10025},
volume = {1},
year = {2020}
}