TY  - JOUR
T1  - Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets Basic process of tumor metastasis
A1  - Cui, Chaochu
A1  - Zhang, Yongxi
A1  - Liu, Gang
A1  - Zhang, Shuhong
A1  - Zhang, Jinghang
A1  - Wang, Xianwei
Y1  - 2021///
KW  - Calcium channel
KW  - cancer metastasis
KW  - epithelial-mesenchymal transition
KW  - tumor microenvironment
KW  - immunosurveillance
KW  - metastatic colonization
JF  - Exploration of Targeted Anti-tumor Therapy
VL  - 2
SP  - 266
EP  - 291
DO  - 10.37349/etat.2021.00046
UR  - https://www.explorationpub.com/Journals/etat/Article/100246
N2  - Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transition, metabolic remodeling, cancer cell intercommunication and the tumor microenvironment including diverse stromal cells, are reported to affect the metastatic process of cancer cells. Calcium ions (Ca2+) are ubiquitous second messengers that manipulate cancer metastasis by affecting signaling pathways. Diverse transporter/pump/ channel-mediated Ca2+ currents form Ca2+ oscillations that can be decoded by Ca2+-binding proteins, which are promising prognostic biomarkers and therapeutic targets of cancer metastasis. This paper presents a review of the advances in research on the mechanisms underlying cancer metastasis and the roles of Ca2+- related signals in these events.
ER  -