@article{Cui2021,
abstract = {Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transition, metabolic remodeling, cancer cell intercommunication and the tumor microenvironment including diverse stromal cells, are reported to affect the metastatic process of cancer cells. Calcium ions (Ca2+) are ubiquitous second messengers that manipulate cancer metastasis by affecting signaling pathways. Diverse transporter/pump/ channel-mediated Ca2+ currents form Ca2+ oscillations that can be decoded by Ca2+-binding proteins, which are promising prognostic biomarkers and therapeutic targets of cancer metastasis. This paper presents a review of the advances in research on the mechanisms underlying cancer metastasis and the roles of Ca2+- related signals in these events.},
author = {Cui, Chaochu and Zhang, Yongxi and Liu, Gang and Zhang, Shuhong and Zhang, Jinghang and Wang, Xianwei},
doi = {10.37349/etat.2021.00046},
journal = {Exploration of Targeted Anti-tumor Therapy},
keywords = {Calcium channel,cancer metastasis,epithelial-mesenchymal transition,immunosurveillance,metastatic colonization,tumor microenvironment},
pages = {266--291},
title = {{Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets Basic process of tumor metastasis}},
url = {https://www.explorationpub.com/Journals/etat/Article/100246},
volume = {2},
year = {2021}
}