@article{10.37349/etat.2026.1002408,
abstract = {Glioblastoma (GB) differs from other malignancies in its pronounced aggressiveness, drug resistance (including with modern chemotherapy and anti-PD-1 immunotherapy), high mortality, and the involvement of transposable elements (TEs) in its development. This is reflected in the high frequency of detection of TE-driven chromothripsis in GB samples (39%). Chromothripsis affects chromosomes 7, 9, and 12, with amplification of the EGFR and MDM2/CDK4 oncogenes. GB is characterized by the expression of multiple transcripts and peptides derived from specific TEs and stimulating an antitumor immune response. At the same time, LINE1 and a number of long terminal repeat-containing retroelements have been described as having a tumor-promoting effect on GB. Therefore, a differentiated approach to treating GB is promising, with inhibition of TEs involved in carcinogenesis and simultaneous activation of the safest and most immunogenic TEs (viral mimicry). For this approach, it has been proposed to use microRNAs derived from TEs and represented in the MDTE database. A review of the scientific literature identified 43 such microRNAs with tumor suppressor properties. However, additional experimental and clinical studies are needed for their possible use before these molecules can be considered as therapeutic targets. Twenty oncogenic microRNAs derived from TEs were also identified. Interactions of these microRNAs with long noncoding RNAs and circular RNAs in GB pathogenesis are also described.},
author = {Mustafin, Rustam},
doi = {10.37349/etat.2026.1002408},
journal = {Exploration of Targeted Anti-tumor Therapy},
elocation-id = {1002408},
title = {Study of the relationship between transposable elements and microRNAs in the development of glioblastoma for its targeted therapy},
url = {https://www.explorationpub.com/Journals/etat/Article/1002408},
volume = {7},
year = {2026}
}