@article{10.37349/etat.2026.1002399,
abstract = {A functional immune system is a key antagonist of cancer cell growth. Cytokines such as interferons (IFNs) promote the onset of inflammation, turn cells into an anti-viral state, and shape the dynamic tumor-immune cell interactome. Recent work illustrates how type I IFNs contribute to the resolution of inflammatory conditions. This involves macrophage-mediated efferocytosis for the clearance of apoptotic cells and the intrinsic capacity of type I IFNs to restrict their own autocrine signaling loops via the IFN-stimulated gene 15 (ISG15) protein. We discuss how this may affect tumor cells and how acetylation-dependent processes can affect the phosphorylation-dependent signaling cascades that augment IFN-dependent gene expression.},
author = {Mieland, Andreas O. and Krämer, Oliver H.},
doi = {10.37349/etat.2026.1002399},
journal = {Exploration of Targeted Anti-tumor Therapy},
elocation-id = {1002399},
title = {Mitochondrial checkpoint for interferon responses in macrophages},
url = {https://www.explorationpub.com/Journals/etat/Article/1002399},
volume = {7},
year = {2026}
}