TY  - JOUR
T1  - Diagnostic and prognostic role of NLR in testicular cancer
AU  - Sarejloo, Shirin
AU  - Babadi, Saghar
AU  - Khanzadeh, Shokoufeh
AU  - Salimi, Amirhossein
AU  - Clark, Alec
AU  - Khazaeli, Dinyar
AU  - Khanzadeh, Monireh
AU  - Ghaedi, Arshin
AU  - Lucke-wold, Brandon
Y1  - 2024///
JO  - Exploration of Targeted Anti-tumor Therapy
VL  - 5
IS  - 6
SP  - 1177
EP  - 1198
DO  - 10.37349/etat.2024.00270
UR  - https://www.explorationpub.com/Journals/etat/Article/1002270
AB  - Background: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa). Methods: The search was conducted on PubMed, Scopus, and Web of Science up to November 21, 2021. Finally, a total of 31 studies were included in this review. Results: NLR was higher in tCa patients compared to healthy controls and benign testis pathologies, and decreased significantly after orchiectomy. An elevated NLR predicts poor prognosis, advanced stage, presence of nodal or distant metastases, contralateral tumor development, lower time-to-cancer specific death, worse OS, and poorer response to chemotherapy. However, NLR could not differentiate between seminomas and non-seminomatous tCa. Discussion: NLR has a significant diagnostic and prognostic value in tCa.
ER  -