TY  - JOUR
T1  - Immunotherapy in thymic epithelial tumors: tissue predictive biomarkers for immune checkpoint inhibitors
AU  - Lucà, Stefano
AU  - Accardo, Marina
AU  - Campione, Severo
AU  - Franco, Renato
Y1  - 2024///
JO  - Exploration of Targeted Anti-tumor Therapy
VL  - 5
IS  - 3
SP  - 465
EP  - 476
DO  - 10.37349/etat.2024.00229
UR  - https://www.explorationpub.com/Journals/etat/Article/1002229
AB  - Thymic epithelial tumors (TETs) are rare malignant neoplasms arising in the thymus gland. Nevertheless, TETs, including thymomas (TMs), thymic carcinomas (TCs), and thymic neuroendocrine neoplasms (TNENs), are the most common mediastinal malignancies overall. A multidisciplinary approach is required for the appropriate diagnostic and therapeutic management of TETs. To date, the main therapeutic strategies are largely depended on the stage of the tumor and they include surgery with or without neoadjuvant or adjuvant therapy, represented by platinum-based chemotherapy, radiotherapy or chemoradiotherapy. Immune checkpoint inhibitors (ICIs) are ongoing under evaluation in the advanced or metastatic diseases despite the challenges related to the very low tumor mutation burden (TMB) and the high incidence of immune-related adverse events in TETs. In this regard, predictive impact of tissue biomarkers expression such as programmed cell death ligand-1 (PD-L1), and other emerging biomarkers, as well as their optimal and shared interpretation are currently under evaluation in order to predict response rates to ICIs in TETs.
ER  -