TY  - JOUR
T1  - Nanomedicine strategies to counteract cancer stemness and chemoresistance
AU  - Liu, Huayu
AU  - Liu, Mingqi
AU  - Zhao, Yanan
AU  - Mo, Ran
Y1  - 2023///
JO  - Exploration of Targeted Anti-tumor Therapy
VL  - 4
IS  - 4
SP  - 630
EP  - 656
DO  - 10.37349/etat.2023.00157
UR  - https://www.explorationpub.com/Journals/etat/Article/1002157
AB  - Cancer stem-like cells (CSCs) identified by self-renewal ability and tumor-initiating potential are responsible for tumor recurrence and metastasis in many cancers. Conventional chemotherapy fails to eradicate CSCs that hold a state of dormancy and possess multi-drug resistance. Spurred by the progress of nanotechnology for drug delivery and biomedical applications, nanomedicine has been increasingly developed to tackle stemness-associated chemotherapeutic resistance for cancer therapy. This review focuses on advances in nanomedicine-mediated therapeutic strategies to overcome chemoresistance by specifically targeting CSCs, the combination of chemotherapeutics with chemopotentiators, and programmable controlled drug release. Perspectives from materials and formulations at the nano-scales are specifically surveyed. Future opportunities and challenges are also discussed.
ER  -