@article{10.37349/etat.2023.00157,
abstract = {Cancer stem-like cells (CSCs) identified by self-renewal ability and tumor-initiating potential are responsible for tumor recurrence and metastasis in many cancers. Conventional chemotherapy fails to eradicate CSCs that hold a state of dormancy and possess multi-drug resistance. Spurred by the progress of nanotechnology for drug delivery and biomedical applications, nanomedicine has been increasingly developed to tackle stemness-associated chemotherapeutic resistance for cancer therapy. This review focuses on advances in nanomedicine-mediated therapeutic strategies to overcome chemoresistance by specifically targeting CSCs, the combination of chemotherapeutics with chemopotentiators, and programmable controlled drug release. Perspectives from materials and formulations at the nano-scales are specifically surveyed. Future opportunities and challenges are also discussed.},
author = {Liu, Huayu and Liu, Mingqi and Zhao, Yanan and Mo, Ran},
doi = {10.37349/etat.2023.00157},
journal = {Exploration of Targeted Anti-tumor Therapy},
pages = {630--656},
title = {{Nanomedicine strategies to counteract cancer stemness and chemoresistance}},
url = {https://www.explorationpub.com/Journals/etat/Article/1002157},
volume = {4},
year = {2023},
number = {4}
}