TY  - JOUR
T1  - Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy
AU  - Chan, Max Kam-Kwan
AU  - Chan, Emily Lok-Yiu
AU  - Ji, Zoey Zeyuan
AU  - Chan, Alex Siu-Wing
AU  - Li, Chunjie
AU  - Leung, Kam-tong
AU  - To, Ka-Fai
AU  - Tang, Patrick Ming-Kuen
Y1  - 2023///
JO  - Exploration of Targeted Anti-tumor Therapy
VL  - 4
IS  - 2
SP  - 316
EP  - 343
DO  - 10.37349/etat.2023.00137
UR  - https://www.explorationpub.com/Journals/etat/Article/1002137
AB  - Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, both anticancer and protumoral actions are reported. Interestingly, increasing evidence suggests that TGF-β enhances disease progression and drug resistance via immune-modulatory actions in the tumor microenvironment (TME) of solid tumors. A better understanding of its regulatory mechanisms in the TME at the molecular level can facilitate the development of precision medicine to block the protumoral actions of TGF-β in the TME. Here, the latest information about the regulatory mechanisms and translational research of TGF-β signaling in the TME for therapeutic development had been summarized.
ER  -