@article{10.37349/etat.2023.00137,
abstract = {Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, both anticancer and protumoral actions are reported. Interestingly, increasing evidence suggests that TGF-β enhances disease progression and drug resistance via immune-modulatory actions in the tumor microenvironment (TME) of solid tumors. A better understanding of its regulatory mechanisms in the TME at the molecular level can facilitate the development of precision medicine to block the protumoral actions of TGF-β in the TME. Here, the latest information about the regulatory mechanisms and translational research of TGF-β signaling in the TME for therapeutic development had been summarized.},
author = {Chan, Max Kam-Kwan and Chan, Emily Lok-Yiu and Ji, Zoey Zeyuan and Chan, Alex Siu-Wing and Li, Chunjie and Leung, Kam-tong and To, Ka-Fai and Tang, Patrick Ming-Kuen},
doi = {10.37349/etat.2023.00137},
journal = {Exploration of Targeted Anti-tumor Therapy},
pages = {316--343},
title = {{Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy}},
url = {https://www.explorationpub.com/Journals/etat/Article/1002137},
volume = {4},
year = {2023},
number = {2}
}