TY  - JOUR
T1  - A brief overview of antitumoral actions of bruceine D
A1  - Sin, Zi Wayne
A1  - Bhardwaj, Vipul
A1  - Pandey, Amit Kumar
A1  - Garg, Manoj
Y1  - 2020///
KW  - anti-inflammatory
KW  - apoptosis
KW  - bruceine D
KW  - cancer
KW  - cancer stem cells
KW  - epithelial-to-mesenchymal transition
KW  - metastasis
KW  - PI3K/AKT/ERK pathway
JF  - Exploration of Targeted Anti-tumor Therapy
VL  - 1
IS  - 4
SP  - 200
EP  - 217
DO  - 10.37349/etat.2020.00013
UR  - https://www.explorationpub.com/Journals/etat/Article/100213
N2  - Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually accompanied with adverse side effects that decrease the quality of patient's lives. As such, natural bioactive compounds have gained an attraction in the scientific and medical community as evidence of their anticancer properties and attenuation of side effects mounted. In particular, quassinoids have been found to exhibit a plethora of inhibitory activities such as anti-proliferative effects on tumor development and metastasis. Recently, bruceine D, a quassinoid isolated from the shrub Brucea javanica (L.) Merr. (Simaroubaceae), has come under immense investigation on its antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. In this review, we have highlighted the antineoplastic effects of bruceine D and its mode of actions in different tumor models.
ER  -