@article{Canonica2022,
abstract = {Prostate cancer (PCa) accounts as the most common non-cutaneous disease affecting males, and as the first cancer, for incidence, in male. With the introduction of the concept of immunoscore, PCa has been classified as a cold tumor, thus driving the attention in the development of strategies aimed at blocking the infiltration/activation of immunosuppressive cells, while favoring the infiltration/activation of anti-tumor immune cells. Even if immunotherapy has revolutionized the approaches to cancer therapy, there is still a window failure, due to the immune cell plasticity within PCa, that can acquire pro-tumor features, subsequent to the tumor microenvironment (TME) capability to polarize them. This review discussed selected relevant soluble factors [transforming growth factor-beta (TGF$\beta$), interleukin-6 (IL-6), IL-10, IL-23] and cellular components of the innate immunity, as drivers of tumor progression, immunosuppression, and angiogenesis within the PCa-TME.},
author = {Palano, Maria Teresa and Gallazzi, Matteo and Cucchiara, Martina and Deh{\`{o}}, Federico and Capogrosso, Paolo and Bruno, Antonino and Mortara, Lorenzo},
doi = {10.37349/etat.2022.00108},
journal = {Exploration of Targeted Anti-tumor Therapy},
number = {5},
pages = {694--718},
title = {{The tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors}},
url = {https://www.explorationpub.com/Journals/etat.2022.1002108},
volume = {3},
year = {2022}
}