TY  - JOUR
T1  - Reactive oxygen species in cardiovascular diseases: an update
AU  - Fei, Juanjuan
AU  - Demillard, Laurie J.
AU  - Ren, Jun
Y1  - 2022///
JO  - Exploration of Medicine
VL  - 3
IS  - 2
SP  - 188
EP  - 204
DO  - 10.37349/emed.2022.00085
UR  - https://www.explorationpub.com/Journals/em/Article/100185
AB  - Cardiovascular diseases are among the leading causes of death worldwide, imposing major health threats. Reactive oxygen species (ROS) are one of the most important products from the process of redox reactions. In the onset and progression of cardiovascular diseases, ROS are believed to heavily influence homeostasis of lipids, proteins, DNA, mitochondria, and energy metabolism. As ROS production increases, the heart is damaged, leading to further production of ROS. The vicious cycle continues on as additional ROS are generated. For example, recent evidence indicated that connexin 43 (Cx43) deficiency and pyruvate kinase M2 (PKM2) activation led to a loss of protection in cardiomyocytes. In this context, a better understanding of the mechanisms behind ROS production is vital in determining effective treatment and management strategies for cardiovascular diseases.
ER  -