@article{10.37349/emed.2025.1001341,
abstract = {Aim: Lung cancer is a leading cause of cancer-related deaths globally, where early and accurate diagnosis significantly improves survival rates. This study proposes an AI-based diagnostic framework integrating U-Net for lung nodule segmentation and a custom convolutional neural network (CNN) for binary classification of nodules as benign or malignant. Methods: The model was developed using the Barnard Institute of Radiology (BIR) Lung CT dataset. U-Net was used for segmentation, and a custom CNN, compared with EfficientNet B0, VGG-16, and Inception v3, was implemented for classification. Due to limited subtype labels and diagnostically ambiguous “suspicious” cases, classification was restricted to a binary task. These uncertain cases were reserved for validation. Overfitting was addressed through stratified 5-fold cross-validation, dropout, early stopping, L2 regularization, and data augmentation. Results: EfficientNet B0 achieved ~99.3% training and ~97% validation accuracy. Cross-validation yielded consistent metrics (accuracy: 0.983 ± 0.014; F1-score: 0.983 ± 0.006; AUC = 0.990), confirming robustness. External validation on the LIDC-IDRI dataset demonstrated generalizability across diverse populations. Conclusions: The proposed AI model shows strong potential for clinical deployment in lung cancer diagnosis. Future work will address demographic bias, expand multi-center data inclusion, and explore regulatory pathways for real-world integration.},
author = {Azhagarasan, Ashwin Kumar and Bhaskaran, Prashanthi and Ramachandran, Arunkumar and Sivalingam, Kalpana},
doi = {10.37349/emed.2025.1001341},
journal = {Exploration of Medicine},
elocation-id = {1001341},
title = {Artificial intelligence framework for lung cancer nodule segmentation and classification using convolutional neural network—from imaging to diagnosis},
url = {https://www.explorationpub.com/Journals/em/Article/1001341},
volume = {6},
year = {2025}
}