TY  - JOUR
TI  - TMAO metaorganismal pathway and chronic inflammatory diseases
AU  - Wang, Zeneng
AU  - Man, Shumei
AU  - Koeth, Robert
PY  - 2025
JO  - Exploration of Medicine
VL  - 6
SP  - 1001339
DO  - 10.37349/emed.2025.1001339
UR  - https://www.explorationpub.com/Journals/em/Article/1001339
AB  - Nutrients containing a trimethylamine (TMA) moiety in their structure can be metabolized by the gut microbiota through enzymatic cleavage of the C-N bond, producing TMA. In the liver, TMA is subsequently oxidized to trimethylamine N-oxide (TMAO) by flavin monooxygenases (FMOs). TMAO exerts pro-atherogenic and pro-inflammatory effects that contribute mechanistically to several chronic inflammatory diseases including cardiovascular disease, chronic kidney disease, obesity, non-alcoholic fatty liver disease, and neurodegenerative diseases. Targeting this metaorganismal pathway may offer substantial health benefits in the prevention and treatment of chronic inflammatory conditions.
ER  -