@article{10.37349/emed.2025.1001339,
abstract = {Nutrients containing a trimethylamine (TMA) moiety in their structure can be metabolized by the gut microbiota through enzymatic cleavage of the C-N bond, producing TMA. In the liver, TMA is subsequently oxidized to trimethylamine N-oxide (TMAO) by flavin monooxygenases (FMOs). TMAO exerts pro-atherogenic and pro-inflammatory effects that contribute mechanistically to several chronic inflammatory diseases including cardiovascular disease, chronic kidney disease, obesity, non-alcoholic fatty liver disease, and neurodegenerative diseases. Targeting this metaorganismal pathway may offer substantial health benefits in the prevention and treatment of chronic inflammatory conditions.},
author = {Wang, Zeneng and Man, Shumei and Koeth, Robert},
doi = {10.37349/emed.2025.1001339},
journal = {Exploration of Medicine},
elocation-id = {1001339},
title = {TMAO metaorganismal pathway and chronic inflammatory diseases},
url = {https://www.explorationpub.com/Journals/em/Article/1001339},
volume = {6},
year = {2025}
}