TY  - JOUR
T1  - The journey of dostarlimab: a successful weapon for cancer treatment
AU  - Ali, Rouchan
AU  - Virendra, Sharma Arvind
AU  - Chawla, Pooja A
Y1  - 2022///
JO  - Exploration of Medicine
VL  - 3
IS  - 6
SP  - 592
EP  - 606
DO  - https://doi.org/10.37349/emed.2022.00116
UR  - https://www.explorationpub.com/Journals/em/Article/1001116
AB  - In a number of malignancies, new immuno-oncology therapies that focus on the programmed cell death 1 (PD-1) have improvised the patient condition along with a positive aftereffect. Monoclonal antibodies (mAbs) directed against PD-1 and its ligand (PD-L1), have been widely used to treat a variety of malignancies, including melanoma, renal cancer, and non-small cell lung cancer (NSCLC). Dostarlimab, a therapeutic anti-PD-1 antibody, was authorised by the United States Food and Drug Administration (FDA) in April 2021 under the trade name JEMPERLI. It is a humanised contrary PD-1 immunoglobulin G 4 (IgG4) mAb, which successfully blocks interaction with PD-L1 and PD-L2 by binding tightly to the PD-1 receptor. This article summarizes the different aspects associated with the dostarlimab, including currently available anti-PD-1/PD-L1 antibodies, pharmacokinetics (PK), pharmacodynamics, adverse reaction, and mechanism of action of dostarlimab, as well as various reported clinical trials.
ER  -