Array ( [0] => Array ( [ArticleId] => 537 [Create_Time] => 2023-04-12 [zipUrl] => https://www.explorationpub.com/uploads/zip/202402/20240226080651.zip [xmlUrl] => https://www.explorationpub.com/uploads/Article/A10131/10131.xml [pdfUrl] => https://www.explorationpub.com/uploads/Article/A10131/10131.pdf [coverUrl] => https://www.explorationpub.com/uploads/Article/A10131/10131_cover.png [JournalsId] => 13 [Title] => Exploration of biomaterials: a multidisciplinary venture [Abstract] => [AbstractComplete] => [Names] => Maryam Tabrizian [Doi] => 10.37349/ebmx.2023.00001 [Published] => January 01, 2024 [Viewed] => 649 [Downloaded] => 34 [Subject] => Editorial [Year] => 2024 [CiteUrl] => https://api.crossref.org/works/10.37349/ebmx.2023.00001 [Inline] => 1 [Type] => 1 [Issue] => 1 [Topic] => 0 [TitleAbbr] => Explor BioMat-X. [Pages] => 2024;1:1–4 [Recommend] => 0 [Keywords] => [DetailTitle] => [DetailUrl] => [Id] => 10131 [ris] => https://www.explorationpub.com/uploads/Article/A10131/380c07116d1facc69232e0574fb41401.ris [bib] => https://www.explorationpub.com/uploads/Article/A10131/e2c4a5283b1068445ca2051cb4322d34.bib [ens] => [Cited] => 0 [Cited_Time] => [CitethisArticle] => Tabrizian M. Exploration of biomaterials: a multidisciplinary venture. Explor BioMat-X. 2024;1:1–4. https://doi.org/10.37349/ebmx.2023.00001 [Jindex] => 0 [CName] => [CEmail] => [Ris_Time] => 2024-02-23 02:04:35 [Bib_Time] => 2024-02-23 02:04:35 [KeysWordContens] => Exploration of biomaterials: a multidisciplinary venture,,,Maryam Tabrizian [PublishedText] => Published [IsEdit] => 0 [AccountId] => 38 ) [1] => Array ( [ArticleId] => 942 [Create_Time] => 2023-11-21 [zipUrl] => https://www.explorationpub.com/uploads/zip/202402/20240228070242.zip [xmlUrl] => https://www.explorationpub.com/uploads/Article/A10132/10132.xml [pdfUrl] => https://www.explorationpub.com/uploads/Article/A10132/10132.pdf [coverUrl] => https://www.explorationpub.com/uploads/Article/A10132/10132_cover.png [JournalsId] => 13 [Title] => Interaction of Pseudomonas aeruginosa with surface-modified silica studied by ultra-high frequency acoustic wave biosensor [Abstract] => Aim: This study aimed to examine the amount of surface non-specific adsorption, or fouling, observed by Pseudomonas aeruginosa (P. aeruginosa) on a quartz crystal based acoustic wave biosensor un [AbstractComplete] =>

Aim:

This study aimed to examine the amount of surface non-specific adsorption, or fouling, observed by Pseudomonas aeruginosa (P. aeruginosa) on a quartz crystal based acoustic wave biosensor under different flow conditions with and without an anti-fouling layer.

Methods:

An electromagnetic piezoelectric acoustic sensor (EMPAS) based on electrode free quartz crystals was used to perform the analysis. Phosphate buffered saline (PBS) was flowed over the crystal surface at various flow rates from 50 μL/min to 200 μL/min, with measurements being taken at the 43rd harmonic (~864 MHz). The crystal was either unmodified, or modified with a monoethylene glycol [2-(3-silylpropyloxy)-hydroxy-ethyl (MEG-OH)] anti-fouling layer. Overnight culture of P. aeruginosa PAO1 (PAO1) in lysogeny broth (LB) was injected into the system, and flow maintained for 30 min.

Results:

The frequency change of the EMPAS crystal after injection of bacteria into the system was found to change based on the flow rate of buffer, suggesting the flow rate has a strong effect on the level of non-specific adsorption. The MEG-OH layer drastically reduced the level of fouling observed under all flow conditions, as well as reduced the amount of variation between experiments. Flow rates of 150 μL/min or higher were found to best reduce the level of fouling observed as well as experimental variation.

Conclusions:

The MEG-OH anti-fouling layer is important for accurate and reproducible biosensing measurements due to the reduced fouling and variation during experiments. Additionally, a flow rate of 150 μL/min may prove better for measurement compared to the current standard of 50 μL/min for this type of instrument.

[Names] => Brian De La Franier, Michael Thompson [Doi] => 10.37349/ebmx.2023.00002 [Published] => January 01, 2024 [Viewed] => 304 [Downloaded] => 21 [Subject] => Original Article [Year] => 2024 [CiteUrl] => https://api.crossref.org/works/10.37349/ebmx.2023.00002 [Inline] => 1 [Type] => 1 [Issue] => 1 [Topic] => 0 [TitleAbbr] => Explor BioMat-X. [Pages] => 2024;1:5–13 [Recommend] => 0 [Keywords] => Anti-fouling, biosensor, acoustic wave, Pseudomonas aeruginosa , flow rates [DetailTitle] => [DetailUrl] => [Id] => 10132 [ris] => https://www.explorationpub.com/uploads/Article/A10132/93d53ce34a6d76fa2c1f931060692f3e.ris [bib] => https://www.explorationpub.com/uploads/Article/A10132/c77575e79ee180680ed587e0e7f1c227.bib [ens] => [Cited] => 0 [Cited_Time] => [CitethisArticle] => De La Franier B, Thompson M. Interaction of Pseudomonas aeruginosa with surface-modified silica studied by ultra-high frequency acoustic wave biosensor. Explor BioMat-X. 2024;1:5–13. https://doi.org/10.37349/ebmx.2023.00002 [Jindex] => 0 [CName] => [CEmail] => [Ris_Time] => 2024-02-23 08:30:52 [Bib_Time] => 2024-02-23 08:30:52 [KeysWordContens] => Interaction of Pseudomonas aeruginosa with surface-modified silica studied by ultra-high frequency acoustic wave biosensor, Anti-fouling, biosensor, acoustic wave, Pseudomonas aeruginosa , flow rates, Aim: This study aimed to examine the amount of surface non-specific adsorption, or fouling, observed by Pseudomonas aeruginosa (P. aeruginosa) on a quartz crystal based acoustic wave biosensor under different flow conditions with and without an anti-fouling layer. Methods: An electromagnetic piezoelectric acoustic sensor (EMPAS) based on electrode free quartz crystals was used to perform the analysis. Phosphate buffered saline (PBS) was flowed over the crystal surface at various flow rates from 50 μL/min to 200 μL/min, with measurements being taken at the 43rd harmonic (~864 MHz). The crystal was either unmodified, or modified with a monoethylene glycol [2-(3-silylpropyloxy)-hydroxy-ethyl (MEG-OH)] anti-fouling layer. Overnight culture of P. aeruginosa PAO1 (PAO1) in lysogeny broth (LB) was injected into the system, and flow maintained for 30 min. Results: The frequency change of the EMPAS crystal after injection of bacteria into the system was found to change based on the flow rate of buffer, suggesting the flow rate has a strong effect on the level of non-specific adsorption. The MEG-OH layer drastically reduced the level of fouling observed under all flow conditions, as well as reduced the amount of variation between experiments. Flow rates of 150 μL/min or higher were found to best reduce the level of fouling observed as well as experimental variation. Conclusions: The MEG-OH anti-fouling layer is important for accurate and reproducible biosensing measurements due to the reduced fouling and variation during experiments. Additionally, a flow rate of 150 μL/min may prove better for measurement compared to the current standard of 50 μL/min for this type of instrument. ,Brian De La Franier, Michael Thompson [PublishedText] => Published [IsEdit] => 0 [AccountId] => 87 ) [2] => Array ( [ArticleId] => 977 [Create_Time] => 2023-12-07 [zipUrl] => https://www.explorationpub.com/uploads/zip/202402/20240223080611.zip [xmlUrl] => https://www.explorationpub.com/uploads/Article/A10133/10133.xml [pdfUrl] => https://www.explorationpub.com/uploads/Article/A10133/10133.pdf [coverUrl] => https://www.explorationpub.com/uploads/Article/A10133/10133_cover.png [JournalsId] => 13 [Title] => Fabrication of anthracite-derived multicolor graphene quantum dots for their potential application in nanomedicine [Abstract] => Aim: This study aims to discover an alternative precursor with abundant source and low cost for multicolor graphene quantum dots (GQDs) preparation and application. Methods: In the current [AbstractComplete] =>

Aim:

This study aims to discover an alternative precursor with abundant source and low cost for multicolor graphene quantum dots (GQDs) preparation and application.

Methods:

In the current study, anthracite-derived multicolor GQDs were prepared at different reaction temperatures (100°–150°C), referring to the GQDs 100, GQDs 120, GQDs 130, and GQDs 150.

Results:

The GQDs 100, GQDs 120, GQDs 130, and GQDs 150 solutions were found to be orange-red, yellow-green, green, and blue under 365 nm excitation UV (ultraviolet) lamp, respectively. The X-ray photoelectron spectroscopy (XPS) data suggests high temperature intensifies oxidation of the amorphous sp3 carbon, resulting in GQDs with higher crystalline structure (Csp2). Compared with the GQDs 100 and GQDs 120, the GQDs 130 and GQDs 150 showed much better biocompatibility, which may attribute to their higher Csp2 composition and smaller size.

Conclusions:

The results suggest that GQDs 130 and GQDs 150 are ideal candidates for nanomedicine applications, e.g., drug/gene delivery and bio-imaging, etc.

[Names] => Hongyu Pan ... Kai Yu [Doi] => 10.37349/ebmx.2023.00003 [Published] => January 01, 2024 [Viewed] => 289 [Downloaded] => 16 [Subject] => Original Article [Year] => 2024 [CiteUrl] => https://api.crossref.org/works/10.37349/ebmx.2023.00003 [Inline] => 1 [Type] => 1 [Issue] => 1 [Topic] => 0 [TitleAbbr] => Explor BioMat-X. [Pages] => 2024;1:14–22 [Recommend] => 0 [Keywords] => Multicolor graphene quantum dots, anthracite, biocompatibility, bio-imaging [DetailTitle] => [DetailUrl] => [Id] => 10133 [ris] => https://www.explorationpub.com/uploads/Article/A10133/3e7d6fefe07b3521c0f6277a015bfeb8.ris [bib] => https://www.explorationpub.com/uploads/Article/A10133/07320acfe28f9d4c612852c4dc5e699d.bib [ens] => [Cited] => 0 [Cited_Time] => [CitethisArticle] => Pan H, Chen J, Zhang W, Chen L, Yoon JY, Li B, et al. Fabrication of anthracite-derived multicolor graphene quantum dots for their potential application in nanomedicine. Explor BioMat-X. 2024;1:14–22. https://doi.org/10.37349/ ebmx.2023.00003 [Jindex] => 0 [CName] => [CEmail] => [Ris_Time] => 2024-02-23 08:06:11 [Bib_Time] => 2024-02-23 08:06:11 [KeysWordContens] => Fabrication of anthracite-derived multicolor graphene quantum dots for their potential application in nanomedicine, Multicolor graphene quantum dots, anthracite, biocompatibility, bio-imaging, Aim: This study aims to discover an alternative precursor with abundant source and low cost for multicolor graphene quantum dots (GQDs) preparation and application. Methods: In the current study, anthracite-derived multicolor GQDs were prepared at different reaction temperatures (100°–150°C), referring to the GQDs 100, GQDs 120, GQDs 130, and GQDs 150. Results: The GQDs 100, GQDs 120, GQDs 130, and GQDs 150 solutions were found to be orange-red, yellow-green, green, and blue under 365 nm excitation UV (ultraviolet) lamp, respectively. The X-ray photoelectron spectroscopy (XPS) data suggests high temperature intensifies oxidation of the amorphous sp3 carbon, resulting in GQDs with higher crystalline structure (Csp2). Compared with the GQDs 100 and GQDs 120, the GQDs 130 and GQDs 150 showed much better biocompatibility, which may attribute to their higher Csp2 composition and smaller size. Conclusions: The results suggest that GQDs 130 and GQDs 150 are ideal candidates for nanomedicine applications, e.g., drug/gene delivery and bio-imaging, etc. ,Hongyu Pan ... Kai Yu [PublishedText] => Published [IsEdit] => 0 [AccountId] => 80 ) [3] => Array ( [ArticleId] => 1074 [Create_Time] => 2024-01-16 [zipUrl] => https://www.explorationpub.com/uploads/zip/202402/20240227023928.zip [xmlUrl] => https://www.explorationpub.com/uploads/Article/A10134/10134.xml [pdfUrl] => https://www.explorationpub.com/uploads/Article/A10134/10134.pdf [coverUrl] => https://www.explorationpub.com/uploads/Article/A10134/10134_cover.png [JournalsId] => 13 [Title] => Journey of medical device development from the bench to the bedside—four real-life examples of commercial biomaterials development [Abstract] => Translating biomaterials research into clinical products is a multidisciplinary yet rewarding journey. It should primarily aim to improve patient treatment and clinical outcomes by addressing unmet [AbstractComplete] =>

Translating biomaterials research into clinical products is a multidisciplinary yet rewarding journey. It should primarily aim to improve patient treatment and clinical outcomes by addressing unmet clinical needs. Four examples of commercial development of biomaterial implants illustrate the diversity of paths, starting from academic research work (AlchiMedics, TISSIUM, Cousin Surgery) or corporate initiatives to develop new products (Medtronic-Sofradim Production). They have been selected from the Translational Research session of the 2022 Conference of the European Society for Biomaterials (ESB) in Bordeaux (France). Commitment, agility, and perseverance were among the key common skills to successfully meet challenges, especially the most unexpected ones. All dimensions of translation projects must be integrated from the start, including the regulatory strategy.

[Names] => Yves Bayon ... Didier Letourneur [Doi] => 10.37349/ebmx.2024.00004 [Published] => January 16, 2024 [Viewed] => 230 [Downloaded] => 17 [Subject] => Review [Year] => 2024 [CiteUrl] => https://api.crossref.org/works/10.37349/ebmx.2023.00004 [Inline] => 1 [Type] => 1 [Issue] => 1 [Topic] => 0 [TitleAbbr] => Explor BioMat-X. [Pages] => 2024;1:23–33 [Recommend] => 0 [Keywords] => Biomaterials, medical devices, translation, clinical development [DetailTitle] => [DetailUrl] => [Id] => 10134 [ris] => https://www.explorationpub.com/uploads/Article/A10134/982e8fba1fc319049b95ceddaef28a8a.ris [bib] => https://www.explorationpub.com/uploads/Article/A10134/b3dbbc6cecc5a465759c626a22c53321.bib [ens] => [Cited] => 0 [Cited_Time] => [CitethisArticle] => Bayon Y, Bureau C, Perreira M, Aubert F, Caillibotte M, Vestberg R, et al. Journey of medical device development from the bench to the bedside—four real-life examples of commercial biomaterials development. Explor BioMat-X. 2024;1:23–33. https://doi.org/10.37349/ebmx.2024.00004 [Jindex] => 0 [CName] => [CEmail] => [Ris_Time] => 2024-01-16 01:17:48 [Bib_Time] => 2024-01-16 01:17:48 [KeysWordContens] => Journey of medical device development from the bench to the bedside—four real-life examples of commercial biomaterials development, Biomaterials, medical devices, translation, clinical development, Translating biomaterials research into clinical products is a multidisciplinary yet rewarding journey. It should primarily aim to improve patient treatment and clinical outcomes by addressing unmet clinical needs. Four examples of commercial development of biomaterial implants illustrate the diversity of paths, starting from academic research work (AlchiMedics, TISSIUM, Cousin Surgery) or corporate initiatives to develop new products (Medtronic-Sofradim Production). They have been selected from the Translational Research session of the 2022 Conference of the European Society for Biomaterials (ESB) in Bordeaux (France). Commitment, agility, and perseverance were among the key common skills to successfully meet challenges, especially the most unexpected ones. All dimensions of translation projects must be integrated from the start, including the regulatory strategy. ,Yves Bayon ... Didier Letourneur [PublishedText] => Published [IsEdit] => 0 [AccountId] => 88 ) [4] => Array ( [ArticleId] => 1142 [Create_Time] => 2024-02-26 [zipUrl] => https://www.explorationpub.com/uploads/zip/202402/20240226104234.zip [xmlUrl] => https://www.explorationpub.com/uploads/Article/A10135/10135.xml [pdfUrl] => https://www.explorationpub.com/uploads/Article/A10135/10135.pdf [coverUrl] => https://www.explorationpub.com/uploads/Article/A10135/10135_cover.png [JournalsId] => 13 [Title] => Fabrication and characterization of pHEMA hydrogel conduit containing GelMA-HaMA IPN for peripheral nerve regeneration [Abstract] => Aim: Small defects after any injury to the periperal nerves results in self-regeneration. However, for larger defects, suturing or grafting are necessary, which may have limitations. Thus, resear [AbstractComplete] =>

Aim:

Small defects after any injury to the periperal nerves results in self-regeneration. However, for larger defects, suturing or grafting are necessary, which may have limitations. Thus, research on nerve guidence conduits is needed without drawbacks. The aim of the study was to develop hydrogel-based conduits containing interpenetrating network (IPN).

Methods:

Methacrylated gelatin (GelMA)-methacrylated hyaluronic acid (HaMA) IPN was filled the poly(2-hydroxyethylmethacrylate) (pHEMA) the outer conduit. Schwann cells (SCs) were used on the pHEMA and the distal end of the tube was injected with netrin-1 to support model SH-SY5Y cells.

Results:

1H-nuclear magnetic resonance (1H-NMR) showed that methacrylation degrees were 94% ± 2% for GelMA and 60% ± 7% for HaMA. The fraction of HaMA increased the degradation rate; pure HaMA degraded in 3 weeks, while pure GelMA in more than 5 weeks. An increase in the fraction of 2-hydroxyethylmethacrylate (HEMA) from 20% to 56% decreased the porosity and the pore size, significantly. SH-SY5Y cells migrated along the conduit in the presence of netrin-1. NeuN expression was increased in 2 weeks indicating neuronal activity.

Conclusions:

SH-SY5Y cells produced neurites in the IPN. pHEMA conduit including GelMA-HaMA IPN is a good candidate for peripheral nerve regeneration applications. As future studies, the conduit will be tested in vivo for nerve regeneration.

[Names] => Damla Arslantunali Sahin ... Vasif Hasirci [Doi] => 10.37349/ebmx.2024.00005 [Published] => February 26, 2024 [Viewed] => 73 [Downloaded] => 5 [Subject] => Original Article [Year] => 2024 [CiteUrl] => https://api.crossref.org/works/10.37349/ebmx.2024.00005 [Inline] => 1 [Type] => 1 [Issue] => 1 [Topic] => 204 [TitleAbbr] => Explor BioMat-X. [Pages] => 2024;1:34–57 [Recommend] => 0 [Keywords] => Peripheral nerve injury, axon regeneration, nerve guidance conduit, hydrogel, poly(2-hydroxyethylmethacrylate), methacrylated gelatin, hyaluronic acid, interpenetrating network [DetailTitle] => Nature-Based Biomaterials for Biomedical Applications [DetailUrl] => https://www.explorationpub.com/Journals/ebmx/Special_Issues/204 [Id] => 10135 [ris] => https://www.explorationpub.com/uploads/Article/A10135/c15dc07d5a3247b822fce3ae3c14a851.ris [bib] => https://www.explorationpub.com/uploads/Article/A10135/c51f153da43870c6305f5e6fc896b9fb.bib [ens] => [Cited] => 0 [Cited_Time] => [CitethisArticle] => Sahin DA, Son CD, Hasirci V. Fabrication and characterization of pHEMA hydrogel conduit containing GelMA-HaMA IPN for peripheral nerve regeneration. Explor BioMat-X. 2024;1:34–57. https://doi.org/10.37349/ebmx.2024.00005 [Jindex] => 0 [CName] => [CEmail] => [Ris_Time] => 2024-02-26 08:26:52 [Bib_Time] => 2024-02-26 08:26:52 [KeysWordContens] => Fabrication and characterization of pHEMA hydrogel conduit containing GelMA-HaMA IPN for peripheral nerve regeneration, Peripheral nerve injury, axon regeneration, nerve guidance conduit, hydrogel, poly(2-hydroxyethylmethacrylate), methacrylated gelatin, hyaluronic acid, interpenetrating network, Aim: Small defects after any injury to the periperal nerves results in self-regeneration. However, for larger defects, suturing or grafting are necessary, which may have limitations. Thus, research on nerve guidence conduits is needed without drawbacks. The aim of the study was to develop hydrogel-based conduits containing interpenetrating network (IPN). Methods: Methacrylated gelatin (GelMA)-methacrylated hyaluronic acid (HaMA) IPN was filled the poly(2-hydroxyethylmethacrylate) (pHEMA) the outer conduit. Schwann cells (SCs) were used on the pHEMA and the distal end of the tube was injected with netrin-1 to support model SH-SY5Y cells. Results: 1H-nuclear magnetic resonance (1H-NMR) showed that methacrylation degrees were 94% ± 2% for GelMA and 60% ± 7% for HaMA. The fraction of HaMA increased the degradation rate; pure HaMA degraded in 3 weeks, while pure GelMA in more than 5 weeks. An increase in the fraction of 2-hydroxyethylmethacrylate (HEMA) from 20% to 56% decreased the porosity and the pore size, significantly. SH-SY5Y cells migrated along the conduit in the presence of netrin-1. NeuN expression was increased in 2 weeks indicating neuronal activity. Conclusions: SH-SY5Y cells produced neurites in the IPN. pHEMA conduit including GelMA-HaMA IPN is a good candidate for peripheral nerve regeneration applications. As future studies, the conduit will be tested in vivo for nerve regeneration. ,Damla Arslantunali Sahin ... Vasif Hasirci [PublishedText] => Published [IsEdit] => 0 [AccountId] => 22 ) )