Emerging Screening Technologies in Drug Discovery
Dr. Matthias Baud E-Mail
Associate Professor in Medicinal Chemistry and Chemical Biology, University of Southampton, Southampton, UK
Screening technologies play a pivotal role for the discovery of novel bioactive agents, but also for the prevention, diagnostic, and treatment or diverse diseases. Throughput, information richness, reliability, time efficiency and cost-effectiveness are some of many important considerations in the design or use of a screening cascade, and ultimately the overall success of a screening campaign. In this rapidly evolving landscape, we aim to provide a timely overview of the recent developments in the field of screening technologies, and recent applications to the development of novel chemical probes and drug candidates in cancer and beyond.
In this Special Issue, we welcome Original Articles and Reviews spanning from fundamental molecular sciences to advanced clinical work. Example themes include (but are not restricted to): in vitro and phenotypic screening, computational/virtual screening, biophysical/biochemical approaches to characterise molecular interactions, compound library design, high-throughput chemical synthesis, combinatorial and diversity-oriented synthesis (DOS), dynamic covalent chemistry (DCC), automation systems, fragment-based methods, DNA-encoded library technologies (DELT), AI for drug design, pan assay interference (PAIN)… Whether established or at an early stage, we particularly encourage submissions describing novel, audacious approaches and ideas with the potential to lead to disruptive technologies in drug discovery.
Keywords: Drug discovery; compound libraries; screening assays; molecular design; PAINs