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    DNA Damage as Target for Therapeutic Intervention

    Submission Deadline: June 10, 2023

    Guest Editor

    Prof. Thomas Efferth E-Mail

    Director, Institute of Pharmaceutical and Biomedical Sciences, Johannes-Gutenberg University of Mainz, Mainz, Germany


    About the Special Issue

    DNA damage is an ever-present challenge to all forms of life on earth and DNA repair is of fundamental importance to maintain the integrity of the genetic material. From endogenous and exogenous DNA damaging agents. Thus, it comes as no surprise that all organisms from pro- to eukaryotes have developed very efficient repair mechanisms during evolution of life of life on earth (e.g., direct lesion reversal, single-strand repair, double-strand repair, translesion synthesis). Nevertheless, DNA damage occur as rare event in the body and contributes to malignancies as initial step in tumorigenesis. DNA-damaging chemotherapeutics and radiotherapy belong to the standard armamentarium of cancer therapy. In the context of a tumor cells, the DNA repair machinery does not contribute to the health maintenance of the body but, by contrast, to resistance to DNA-damaging drugs and eventually to failure of chemotherapy and the death of cancer patients. While numerous compounds have been described in the past to inhibit DNA repair in tumor cells in an attempt to re-sensitize tumor cells to chemo- and radiotherapy. In the recent years, there has been a paradigm change from cytotoxic to targeted treatment to improve the efficacy and specificity of tumor therapy. In this context, DNA recognition and repair proteins gained much attention as exquisite targets for cancer therapy.
    With the current special issue, we provide a forum to open an interdisciplinary discussion for scientists and clinicians from diverse disciplines to present innovative and thriving concepts how current cancer treatment could benefit from targeting DNA damage and repair. We welcome manuscript from diverse fields such as pharmacology (of synthetic and natural compounds), medicinal chemistry, cell and molecular biology, systems and network pharmacology, and all related disciplines in medicine dealing with DNA damage as target for therapeutic intervention.
    The aim is to provide a comprehensive overview of the current understanding and span a bow from basic to translational and clinical aspects. This special issue should enable the reader to gain the fundamental knowledge of current cutting-edge research.

    Keywords: Cell biology; DNA repair mechanisms; targeted chemo- and radiotherapy; medicinal chemistry; molecular biology; pharmacology; radiotherapy; oncology

    Call for Papers

    Published Articles

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    • Aims and Scope
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    • Ongoing Special Issues
      Off-Label Drugs and -Omics Data in Cancer Treatment
      COVID-19 and Cancer
      Antibody-Drug Conjugates
      The Role of Bcl-2 Family Proteins in Cancer Progression and Their Relevance to Cancer Therapy
      Gene Delivery Approach to Fight Cancer
      The Implementation of Liquid Biopsy in Clinical Practice for Different Solid Tumor
      Cancer Immunotherapy and Tumor Microenvironment
      Theranostic Frontiers in Neuro-Oncology
      Plant Extracts as an Infinite Resource for New Anticancer Agents
      Cancer Stem Cell Targeting Therapy
      Emerging Screening Technologies in Drug Discovery
      Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
      Artificial Intelligence for Precision Oncology
      Integrated Approaches for Non-Small-Cell Lung Cancer
      Innovative Strategies to Target Triple-negative Breast Cancer
      DNA Damage as Target for Therapeutic Intervention
      Therapeutic Targeting of the Tumor Microenvironment
      Molecular Targeted Therapy for Cancer
      Novel Strategies and Targets for Immunotherapy of Cancer
      Molecular Diagnosis and Personalized Therapy of Cancer
      Recent Approaches in Tumor Metabolism
      Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
      Posttranslational Modifications in Health and Disease
    • Completed Special Issues
      Liquid Biopsy in Thoracic Cancer
      Targeting Transcription Factors for Cancer Therapy
      Immunotherapy in Cancer Patients
      Calcium Signaling Apparatus in Cancers
      Proteolysis Targeting Chimera (PROTAC)
      Precision Medicine for Cholangiocarcinoma
      Endocrine Resistant Breast Cancer
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