• Special Issue Topic

    Glia and Neuroprotection

    Submission Deadline: August 31, 2022

    Guest Editor

    Prof. Jose Miguel Soria E-Mail

    Professor, Biomedical Science Department, CEU Cardenal Herrera University, Plaza Reyes Catolicos 19,03204 Elche (Alicante) Spain

    Research Keywords: brain; invitro culture; stem cell; neuroprotective therapy; cell biology

    About the Special Issue

    Glial cells are key homeostatic cells of the central nervous system. The cooperation of glial cells with neurons at several levels, including ion and water homeostasis, chemical signal transmission, blood flow regulation, immune and oxidative stress defense, supply of metabolites and neurogenesis is crucial. Besides, glial cells are also important for viability and maturation of stem-cell derived neurons. Neurons critically depend on intrinsic protective and supportive properties of astrocytes and other glial cells. Conversely, all forms of pathogenic stimuli which disturb astrocytic functions compromise neuronal functionality and viability. Support of neuroprotective functions of astrocytes is thus an important strategy for enhancing neuronal survival and improving outcomes in disease states.

    In this special issue, our main interest will be in studies investigating specific aspects of glial cell response in the neuroprotection within the CNS. We take particular interest in manuscripts reporting new evidence demonstrating glial participation in neurodegenerative disorders, brain damage and brain cancer, anti-inflammatory or neuroprotective treatments that may improve disease prognosis, and basic science studies conducted in disease models illustrating mechanisms of neuroprotection and/or the beneficial or adverse effects of drugs.

    We invite investigators to contribute both original articles and review articles. Potential topics include, but are not limited to:

    · Glial cell response and neuroprotection

    · Neuroinflammation and glial cell responses

    · Innate and adaptive glia responses in the CNS

    · Brain neuroprotection

    · Cross-talk between the glial cells and neurons

    · Brain damage and neuroprotective therapy

    · Effects of aging on the function of glial cells

    · Preclinical studies of neuroprotective therapeutics

    Keywords: glial cells; neuroprotection; central nervous system; neuronal survival, astrocytes

    Call for Papers

    Published Articles

    Open Access
    Neuroprotective astroglial response to neural damage and its relevance to affective disorders
    Astrocytes not only support neuronal function with essential roles in synaptic neurotransmission, action potential propagation, metabolic support, or neuroplastic and developmental adaptations. They [...] Read more.
    José Javier Miguel-Hidalgo
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:328–345
    DOI: https://doi.org/10.37349/ent.2023.00054
    Times Cited: 0
    Open Access
    Innate and adaptive glial cell responses in Alzheimer’s disease
    Alzheimer’s disease (AD), which affects around twenty-seven million people globally, is an aging-related neurodegenerative condition characterized by the extracellular deposition of misfolded amyl [...] Read more.
    Ankita Singh, Tiratha Raj Singh
    Published: April 03, 2023 Explor Neuroprot Ther. 2023;3:90–104
    DOI: https://doi.org/10.37349/ent.2023.00039
    Times Cited: 0
    Open Access
    Blockage of thrombospondin 4 secreted by spinal astrocytes may be a promising therapeutic target in the treatment of neuropathic pain
    Neuropathic pain (NP), which is difficult to treat, remains a heavy burden for both individuals and society. The efficacy of current treatments is insufficient. The pathophysiology of NP is still no [...] Read more.
    Neslihan Düzenli ... Aytül Önal
    Published: October 31, 2022 Explor Neuroprot Ther. 2022;2:226–241
    DOI: https://doi.org/10.37349/ent.2022.00030
    Times Cited: 0